My choice for Paper of the Week this week is "cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue," by Loo, Cheng, Tiirikainen, Lum-Jones, Seifried, et al. (2012) appearing in PLoS One.
I find this article of interest because I feel that many GWAS hits for disease risk will serve to alter expression of a near or distant gene(s) in an allele-specific manner. This group looked at gene expression differences between tissues that were either colorectal tumors or their paired, adjacent normal tissue, and then associated those gene expression differences with allelic variation. Assaying 40 individuals was sufficient to identify 3 SNPs affecting expression of 4 genes: ATP5C1, DLGAP5, NOL3 and DDX28.
A link to this paper is here.
Loo LWM, Cheng I, Tiirikainen M, Lum-Jones A, Seifried A, et al. (2012) cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue. PLoS ONE 7(2): e30477.