tag:blogger.com,1999:blog-8284945886307996607.post1633534215063773949..comments2023-04-07T04:11:24.446-07:00Comments on Variable Genome: The Complexity of a Complex DisorderLarry_Parnellhttp://www.blogger.com/profile/12512295496896559084noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-8284945886307996607.post-52994738203433328192010-05-05T04:50:15.185-07:002010-05-05T04:50:15.185-07:00...
and this communication (only change OMIM/GO t......<br /><br />and this communication (only change OMIM/GO terms by 'individual' clinical diagnostic and mouse/rat gene expression profiles by 'personal' genome sequence)...<br /><br />http://www2007.org/workshops/paper_146.pdf<br /><br />...with one single repository or multilocated data accessed via Semantic Web Workflow (still no clear future for this last well-known text-mining project?!).Juan Ruanohttps://www.blogger.com/profile/00389517822905597641noreply@blogger.comtag:blogger.com,1999:blog-8284945886307996607.post-66361913965658044462010-05-05T04:16:05.947-07:002010-05-05T04:16:05.947-07:00...
Similar to the idea of this paper...
Campill......<br /><br />Similar to the idea of this paper...<br /><br />Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. Drug target identification using side-effect similarity. Science. 2008 Jul 11;321(5886):263-6.<br /><br />...where side-effect profiles (phenotype) helps to find molecular drug target -protein and/or pathway- (complex disease associate genes).Juan Ruanohttps://www.blogger.com/profile/00389517822905597641noreply@blogger.comtag:blogger.com,1999:blog-8284945886307996607.post-54263300015232730262010-05-05T03:26:58.192-07:002010-05-05T03:26:58.192-07:00In my opinion one question is how realistic is any...In my opinion one question is how realistic is any definition of a 'reference genome'?. Speccially now that next gen of genome sequencers are coming to hospitals!<br /><br />Thats is very important for designing complex diseases aproach.<br />With no 'realistic standard genome' (in my opinion there is no sense for using 'consensus genome' in the future), my propose is to use phenotypes (phenomes) as multiple references to study a single complex disease such hypertension. <br />i.e.:<br />genome 1: obese+CVD+inflammatory arthritis<br />genome 2: Rheumatic arthritis+gota+hypertension<br />genome 3: Healthy<br />genome 4: Healthy<br />genome 5: colon cancer+hypertension+obese<br />genome 6: pneumonia+VIH infection+Hodgkin Disease+obesity<br />(...)<br /><br />All these information (genome sequences and phenotypes-via text mining from hospitals' reports) in a public (?) repository.<br /><br />...and 'blasting' genome-phenome 'strings'.<br /><br />Much more complicate, of course.<br /><br />---------<br />Hi Larry, now a follower!<br />Bests from SpainJuan Ruanohttps://www.blogger.com/profile/00389517822905597641noreply@blogger.comtag:blogger.com,1999:blog-8284945886307996607.post-52429473690480502982010-04-30T00:45:21.630-07:002010-04-30T00:45:21.630-07:00This is interesting - although I don't have ac...This is interesting - although I don't have access to full paper. 788 genes is a lot - one question is how many genes are mutated in other rat strains compared to the reference - i.e. how many of these 788 are really linked to hypertension? Is there any discussion of this in the paper?Keith Grimaldihttps://www.blogger.com/profile/03340553707811672190noreply@blogger.com